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Ginkgolide C

CAS No. 15291-76-6

Ginkgolide C( BN 52022 | 1,7-dihydroxy Ginkgolide A )

Catalog No. M12143 CAS No. 15291-76-6

Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Ginkgolide C
  • Note
    Research use only, not for human use.
  • Brief Description
    Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
  • Description
    Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.(In Vitro):Ginkgolide C (3-100 μM) has no significant effect on 3T3-L1 cell viability, but suppresses adipogenesis in 3T3-L1 cells followling 24 h treatment. Ginkgolide C (10-100 μM) significantly suppresses lipid accumulation compared with the control group and also significantly promotes glycerol release in 3T3-L1 adipocytes. Ginkgolide C suppresses PPAR-α and PPAR-γ expression and decreases C/EBPα, C/EBPβ, and SREBP-1c expression in differentiated 3T3-L1 adipocytes. In addition, Ginkgolide C (3-100 μM) suppress adipogenesis-related protein (FAS, LPL, and aP2) and mRNA expression in a dose-dependent manner in differentiated 3T3-L1 adipocytes. Ginkgolide C (3-100 μM) also significantly promotes Sirt1 production and increases phosphorylation of AMPKα and ACC-1 in a concentration-dependent manner. Ginkgolide C (1, 10, 50, 100, 500 mM) significantly reduces the collagen (10 mg/mL)-stimulated rat platelet aggregation in a dose-dependent manner. Ginkgolide C (50, 100 mM) causes pro-MMP-9 (92-kDa) to form an activated MMP-9 (86-kDa) in collagen-stimulated platelets.
  • In Vitro
    Ginkgolide C (3-100?μM) has no significant effect on 3T3-L1 cell viability, but suppresses adipogenesis in 3T3-L1 cells followling 24?h treatment. Ginkgolide C (10-100?μM) significantly suppresses lipid accumulation compared with the control group and also significantly promotes glycerol release in 3T3-L1 adipocytes. Ginkgolide C suppresses PPAR-α and PPAR-γ expression and decreases C/EBPα, C/EBPβ, and SREBP-1c expression in differentiated 3T3-L1 adipocytes. In addition, Ginkgolide C (3-100 μM) suppress adipogenesis-related protein (FAS, LPL, and aP2) and mRNA expression in a dose-dependent manner in differentiated 3T3-L1 adipocytes. Ginkgolide C (3-100 μM) also significantly promotes Sirt1 production and increases phosphorylation of AMPKα and ACC-1 in a concentration-dependent manner. Ginkgolide C (1, 10, 50, 100, 500 mM) significantly reduces the collagen (10 mg/mL)-stimulated rat platelet aggregation in a dose-dependent manner. Ginkgolide C (50, 100 mM) causes pro-MMP-9 (92-kDa) to form an activated MMP-9 (86-kDa) in collagen-stimulated platelets.
  • In Vivo
    ——
  • Synonyms
    BN 52022 | 1,7-dihydroxy Ginkgolide A
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    15291-76-6
  • Formula Weight
    440.4
  • Molecular Formula
    C20H24O11
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    C[C@@H]1C(O[C@H]2[C@@H]([C@]34[C@@H]5OC([C@@]3([C@@]12O)O[C@@H]6OC([C@@H]([C@]46[C@H](C(C)(C)C)[C@H]5O)O)=O)=O)O)=O
  • Chemical Name
    Ginkgolide A, 1,7-dihydroxy-, (1alpha,7beta)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liou CJ, et al. Evid Based Complement Alternat Med. 2015;2015:298635.
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